Researchers find brain circuitry that raises anxiety during nicotine withdrawal

Anxiety associated with smoking cessation is a common side effect of nicotine withdrawal. We all know, Cigarettes are highly addictive, and when you're trying to quit it's not unusual to feel a heightened level of anxiety.

A new study may offer smokers a promising breakthrough as researchers have identified the neural circuit and chemical signals that appear to cause anxiety during periods of nicotine withdrawal.
"Increased anxiety is a prominent nicotine withdrawal symptom that contributes to relapse in smokers attempting to quit," lead researcher and neuropsychiatrist, Andrew Tapper, from the University of Massachusetts in the US, said in a press release.
"We identified a novel circuit in the brain that becomes active during nicotine withdrawal, specifically increasing anxiety."


The study reveled many discoveries about interconnected brain mechanisms that induce anxiety during nicotine withdrawal, and possible ways to derail these mechanisms in order to treat, or even prevent the especially troublesome symptom.

They confirmed that this region is activated during nicotine withdrawal, and found that it appears to be responsible for feelings of increased anxiety. Experiments leading to the multiple, related findings were conducted over several years by the laboratories at UMMS and The Scripps Research Institute of La Jolla, California.

The study is published online in the journal Nature Communications.

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